Nanoprodrugs encapsulated with mesoporous silica nanoparticles for combined with photothermal therapy for the treatment and care of gastric cancer

Abstract In this study, mesoporous silica nanoparticles (MSNs) were surface-modified with polymer poly(HEMA-co-PEGMA via surface-initiated atom transfer radical polymerization and a multifunctional nanoplatform MSNP@poly(HEMA-co-PEGMA-g-doxorubicin (DOX)/Rhodamine 6 G (R6G) was developed to combine photothermal (PTT) chemotherapy therapy effectively. PTT induced by near-infrared (NIR) radiations might further destroy gastric cancer cell lines while the small-dye molecule co-loaded into MSNP pores. A 65 % higher cumulative drug release over 50-h occurs when cis-aconitic anhydride link breaks under low-pH stimulation (typical physiological environment). High temperatures accelerated reversible covalent bond breakage. The accumulative of increased 24.3 %, illustrating that can decrease time needed complete blood concentrations %. More than 90% tumour cells destroyed after 48 h following exposure NIR light irradiation prodrug delivery system, compared DOX alone in vitro cytotoxicity tests. Because this, rapidly chemical breaking activity MSNP@poly(HEMA-co-PEGMA-g-DOX/R6G) synergic impact chemotherapy, which offers tremendous promise combination treatment care therapy.